Turan Arzu Akcay, Karayel Ferah, Akyildiz Elif U, Ozdes Taskin, Yilmaz Eyyup, Pakis Isil
Ministry of Justice, Council of Forensic Medicine, Istanbul, Turkey.
Am J Forensic Med Pathol. 2008 Dec;29(4):354-7. doi: 10.1097/PAF.0b013e3181859fe3.
Eosinophils are associated with various disorders, such as allergic or hypersensitivity reactions, parasitic diseases, connective tissue diseases, certain neoplastic diseases (Hodgkin's disease, lymphomas, and carcinomas), and various immune deficiency states. Eosinophils can infiltrate any tissue and can cause tissue damage. Heart, has been demonstrated to be the most extensively involved and toxicity of eosinophils is well-established on cardiac tissue. We describe 3 cases with extensive eosinophilic infiltration without endomyocardial fibrosis. All patients died after a short clinical course with rapidly progressive heart failure. Bronchial asthma, hydatid disease and drug reaction were considered as possible etiologies of eosinophilia in case 1 and case 2. Case 3 was considered to fall into the "idiopathic hypereosinophilic syndrome" in which no underlying causes for eosinophilia could be identified.
嗜酸性粒细胞与多种疾病相关，如过敏或超敏反应、寄生虫病、结缔组织病、某些肿瘤性疾病（霍奇金病、淋巴瘤和癌）以及各种免疫缺陷状态。嗜酸性粒细胞可浸润任何组织并可导致组织损伤。心脏已被证明是受累最广泛的器官，嗜酸性粒细胞对心脏组织的毒性已得到充分证实。我们描述了3例无心内膜心肌纤维化的广泛嗜酸性粒细胞浸润病例。所有患者在临床病程较短后均死于快速进展的心力衰竭。支气管哮喘、包虫病和药物反应被认为是病例1和病例2中嗜酸性粒细胞增多的可能病因。病例3被认为属于“特发性高嗜酸性粒细胞综合征”，其中嗜酸性粒细胞增多的潜在病因无法确定。
