癌症干细胞、内皮祖细胞和间充质干细胞：重温“种子与土壤”理论
Cancer stem cells, endothelial progenitors, and mesenchymal stem cells: "seed and soil" theory revisited.
作者信息
Lin Edward H, Jiang Yixing, Deng Yanhong, Lapsiwala Ritu, Lin Tongyu, Blau C Anthony
机构信息
Division of Medical Oncology and Hematology, University of Washington, Fred Hutchinson Cancer Research Center, Seattle, WA.
出版信息
Gastrointest Cancer Res. 2008 Jul;2(4):169-74.
Abstract
Isolation of putative cancer stem cells (CSCs) in various tumors has generated much excitement among researchers who consider these cells the potential "culprits" behind resistance to conventional therapy. Both cancer and cardiovascular disease are believed to be stem cell disorders involving circulating endothelial progenitors (CEPs) and mesenchymal stem cells (MSCs). CD133 and CD44, markers of CSCs in many tumors, also enrich CEPs and MSCs, respectively. We propose an integrated tumorigenesis model that involves all three interdependent stem cell (CSC, CEP, MSC) compartments by revisiting the "seed and soil" model. Developing therapeutics that can effectively target CSCs and spare normal cardiovascular tissue will remain a challenge. Preliminary laboratory and clinical data on monitoring and targeting colon CSCs, using such a modeling system, are discussed.
摘要
在各种肿瘤中分离假定的癌症干细胞（CSCs），这在研究人员中引起了极大的兴奋，他们认为这些细胞是传统疗法耐药背后的潜在“罪魁祸首”。癌症和心血管疾病都被认为是涉及循环内皮祖细胞（CEPs）和间充质干细胞（MSCs）的干细胞疾病。许多肿瘤中CSCs的标志物CD133和CD44，分别也富集CEPs和MSCs。我们通过重新审视“种子与土壤”模型，提出了一个涉及所有三个相互依赖的干细胞（CSC、CEP、MSC）区室的综合肿瘤发生模型。开发能够有效靶向CSCs并使正常心血管组织免受影响的疗法仍将是一项挑战。文中讨论了使用这样一个建模系统监测和靶向结肠CSCs的初步实验室和临床数据。
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本文引用的文献
1
Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis.
Science. 2008 Jan 11;319(5860):195-8. doi: 10.1126/science.1150224.
2
Circulating endothelial progenitor cells correlate to stage in patients with invasive breast cancer.
Breast Cancer Res Treat. 2008 Jan;107(1):133-8. doi: 10.1007/s10549-007-9519-6. Epub 2007 Feb 15.
3
Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: results from the BICC-C Study.
J Clin Oncol. 2007 Oct 20;25(30):4779-86. doi: 10.1200/JCO.2007.11.3357.
4
Identification of stem cells in small intestine and colon by marker gene Lgr5.
Nature. 2007 Oct 25;449(7165):1003-7. doi: 10.1038/nature06196. Epub 2007 Oct 14.
5
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis.
Nature. 2007 Oct 4;449(7162):557-63. doi: 10.1038/nature06188.
6
Development and characterization of gemcitabine-resistant pancreatic tumor cells.
Ann Surg Oncol. 2007 Dec;14(12):3629-37. doi: 10.1245/s10434-007-9583-5. Epub 2007 Oct 2.
7
CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway.
Oncogene. 2008 Mar 13;27(12):1749-58. doi: 10.1038/sj.onc.1210811. Epub 2007 Sep 24.
8
Wnt signaling, stem cells, and the cellular origin of breast cancer.
Stem Cell Rev. 2007 Jun;3(2):157-68. doi: 10.1007/s12015-007-0025-3.
9
[Chemoresistance of CD133(+) tumor stem cells from human brain glioma].
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2007 Aug;32(4):568-73.
10
Impact of complete response to chemotherapy on overall survival in advanced colorectal cancer: results from Intergroup N9741.
J Clin Oncol. 2007 Aug 10;25(23):3469-74. doi: 10.1200/JCO.2007.10.7128.
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