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[糖尿病坏疽行开放性或闭合性小截肢术?]

[Open or closed minor amputation for diabetic gangrene?].

作者信息

Ozdemir S

机构信息

Klinik für Endokrinologie, Diabetologie und Rheumatologie der Heinrich-Heine-Universität Düsseldorf.

出版信息

Vasa. 2009 Feb;38 Suppl 74:54-61. doi: 10.1024/0301-1526.38.S74.54.

Abstract

BACKGROUND

Amputation below the ankle at the diabetic foot is rarely successful, if carried out as closed amputation (with primary wound closure).

AIM OF THE STUDY

To assess the outcome of open and closed (minor) amputations in diabetic patients from three hospitals. Patient charts including pathohistology reports were evaluated.

PATIENTS

A total of 80 diabetic patients were considered, of whom 47 had critical foot ischaemia (CFI) Fontaine stage IV, 5 had endstage renal failure with haemodialysis treatment, and 72 had polyneuropathy.

RESULTS

During 96 procedures, 60 toes and 48 metatarsal bones were amputated. A closed amputation (CA, n=54), or an open amputation (OA, n=42) had been performed, at the discretion of the surgeons. Toes rather than metatarsal bones were amputated more often with CA than with OA (p=0.0018). Following CA, 14 wounds (26%) healed by primary intention, whereas 40 wound did not; in 15 cases (28%), reamputations were required. Following OA, 26 wounds (62%) healed by secondary intention, and 14 cases (33%) required reamputation. Histopathology revealed osteomyelitis at the osteotomy site in 34 cases (64%) of CA, versus 31 cases (78%) of OA. Following CA, 77% of 9 cases without CFI, and with healthy bone at the osteotomy site healed by primary intention, versus 4% of 25 cases with CFI and osteomyelitis at the osteotomy site (p<0.0001).

CONCLUSION

Closed amputation was successful only in absence of CFI and of osteomyelitis at the osteotomy site. The extension of osteomyelitis was grossly underestimated. Preoperative MR imaging (rather than X-ray) to diagnose osteomyelitis could improve the outcome of a closed minor amputation, and justify its preferred application at the diabetic foot.

摘要

背景

对于糖尿病足患者,若采用闭合性截肢术(一期伤口缝合),踝关节以下截肢很少成功。

研究目的

评估来自三家医院的糖尿病患者开放性和闭合性(小型)截肢的结果。对包括病理组织学报告在内的患者病历进行评估。

患者

共纳入80例糖尿病患者,其中47例为严重足部缺血(CFI)Fontaine Ⅳ期,5例为接受血液透析治疗的终末期肾衰竭患者,72例患有多发性神经病变。

结果

在96例手术中,共截肢60个趾头和48块跖骨。外科医生根据情况进行了闭合性截肢(CA,n = 54)或开放性截肢(OA,n = 42)。与OA相比,CA更多地进行趾头而非跖骨的截肢(p = 0.0018)。CA术后,14例伤口(26%)一期愈合,而40例伤口未一期愈合;15例(28%)需要再次截肢。OA术后,26例伤口(62%)二期愈合,14例(33%)需要再次截肢。组织病理学显示,CA组34例(64%)截骨部位存在骨髓炎,OA组为31例(78%)。CA术后,9例无CFI且截骨部位骨质健康的患者中,77%一期愈合,而25例截骨部位有CFI和骨髓炎的患者中,4%一期愈合(p < 0.0001)。

结论

闭合性截肢仅在不存在CFI且截骨部位无骨髓炎时成功。骨髓炎的范围被严重低估。术前采用磁共振成像(而非X线)诊断骨髓炎可改善闭合性小型截肢的结果,并证明其在糖尿病足中的优先应用是合理的。

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