Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Pécs, H-7624 Pécs, Hungary.
Fertil Steril. 2010 May 1;93(7):2281-4. doi: 10.1016/j.fertnstert.2009.01.085. Epub 2009 Mar 3.
To evaluate the effect of low-dose aspirin therapy on ovarian hyperstimulation syndrome (OHSS) in an unselected group of patients undergoing in vitro fertilization (IVF).
Randomized clinical trial.
Division of Reproductive Medicine at the Department of Obstetrics and Gynecology, University of Pécs, Faculty of Medicine, Pécs, Hungary.
PATIENT(S): Patients who underwent IVF between 2000 and 2006.
INTERVENTION(S): Initiation of 3154 IVF cycles, for which gonadotropin-releasing hormone agonist was used in 2425 cycles; 1503 cycles randomly selected for low-dose aspirin treatment starting from the first day of controlled ovarian hyperstimulation compared with no treatment in the remaining 922 cycles.
MAIN OUTCOME MEASURE(S): The incidence of severe or critical OHSS and the rate of clinical pregnancy.
RESULT(S): During this time period, 45 cases of severe OHSS were detected. Only two of the OHSS patients had received aspirin previously.
CONCLUSION(S): Based on our preliminary results, introduction of low-dose aspirin therapy during ovulation induction for the prevention of OHSS in high-risk patients should be considered.
评估小剂量阿司匹林治疗对体外受精（IVF）中未选择患者卵巢过度刺激综合征（OHSS）的影响。
随机临床试验。
匈牙利佩奇大学妇产科生殖医学科。
2000 年至 2006 年间接受 IVF 的患者。
启动 3154 个 IVF 周期，其中 2425 个周期使用促性腺激素释放激素激动剂；随机选择 1503 个周期，从控制性卵巢过度刺激的第一天开始接受小剂量阿司匹林治疗，而其余 922 个周期不进行治疗。
严重或临界 OHSS 的发生率和临床妊娠率。
在此期间，检测到 45 例严重 OHSS。只有两名 OHSS 患者之前接受过阿司匹林治疗。
根据我们的初步结果，对于高危患者，在排卵诱导期间引入小剂量阿司匹林治疗以预防 OHSS 应予以考虑。
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