转移性外阴克罗恩病与英夫利昔单抗：一例报告
Metastatic vulval Crohn's disease and infliximab: a case report.
作者信息
Tritton Sara M, Whyte Liesel, Fischer Gayle
机构信息
Department of Dermatology, Level 11, Royal North Shore Hospital, St. Leonards, Sydney, New South Wales 2065, Australia.
出版信息
J Reprod Med. 2009 Jan;54(1):41-4.
BACKGROUND
Metastatic vulval Crohn's disease is uncommon, and diagnosis is frequently delayed. Topical therapy is often ineffective, and systemic immunosuppressive agents are required.
CASE
A 32-year-old Caucasian female with known gastrointestinal Crohn's disease presented with a 7-year history of vulvitis. Perianal biopsy demonstrated typical granulomas. Her disease was resistant to treatment with prednisone and azathioprine; however, infliximab effected good control, and she remains well on 8 weekly infusions 1 year later.
CONCLUSION
Biopsy should be performed in patients with vulvitis who have Crohn's disease to rule out metastatic involvement. Infliximab was successfully used in this case to control Crohn's vulvitis.
背景
转移性外阴克罗恩病并不常见，诊断常常延迟。局部治疗往往无效，需要使用全身免疫抑制剂。
病例
一名32岁患有胃肠道克罗恩病的白人女性，有7年外阴炎病史。肛周活检显示典型的肉芽肿。她的疾病对泼尼松和硫唑嘌呤治疗耐药；然而，英夫利昔单抗有效控制了病情，1年后她每8周输注一次，情况良好。
结论
对于患有克罗恩病的外阴炎患者应进行活检以排除转移性累及。本病例中成功使用英夫利昔单抗控制了克罗恩病外阴炎。
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