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[人类昼夜节律的个体发生]

[Ontogenesis of circadian rhythm in the human].

作者信息

Pringuey D, Tible O, Cherikh F

机构信息

Fédération du Sommeil, CHU Pasteur Nice.

出版信息

Encephale. 2009 Jan;35 Suppl 2:S46-52. doi: 10.1016/S0013-7006(09)75533-2.

Abstract

Ontogenesis of circadian rhythms in human beings, the history of the development of synchronisation of the daily rhythm describes the deployment of an adaptive capacity providing vital biological linkage to the environment. Methods for dating the stages in this temporal organisation have advanced and the genetics approach to the circadian cycle is dominated by studies of the maturation of the awake-asleep cycle. Disease involves the functional regression to one of the different stages of genesis or alternatively will involve a pathological lesion. Circadian dysfunction is characterised by loss of amplitude and multi-day fragmentation, correction of which requires control of multi-day pressure and within-day stabilisation.

摘要

人类昼夜节律的个体发生,即日常节律同步化的发展历程,描述了一种适应性能力的展开,这种能力为与环境建立至关重要的生物联系提供了支持。确定这一生物钟组织中各阶段的方法已经取得进展,而对昼夜节律周期的遗传学研究主要集中在清醒 - 睡眠周期的成熟过程。疾病涉及到向个体发生的不同阶段之一的功能退化,或者可能涉及病理损伤。昼夜节律功能障碍的特征是振幅丧失和多日节律紊乱,对此进行纠正需要控制多日压力并实现日内稳定。

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