脓毒症与脓毒性休克：一段历史

Sepsis and septic shock: a history.

作者信息

Funk Duane J, Parrillo Joseph E, Kumar Anand

机构信息

Anesthesiology and Critical Care, University of Manitoba, Manitoba, Canada.

出版信息

Crit Care Clin. 2009 Jan;25(1):83-101, viii. doi: 10.1016/j.ccc.2008.12.003.

DOI:10.1016/j.ccc.2008.12.003

PMID:19268796

Abstract

Infectious disease has been a leading cause of death in humans since the first recorded tabulations. From Hippocrates and Galen, to Lister, Fleming and Semmelweiss, this article reviews the notable historical figures of sepsis research. The early descriptions and theories about the etiology (microbial pathogens), pathogenesis (toxins and mediators), and treatment of sepsis-associated disease are also discussed.

摘要

自首次有记录的统计以来，传染病一直是人类死亡的主要原因。从希波克拉底和盖伦，到李斯特、弗莱明和塞麦尔维斯，本文回顾了脓毒症研究领域的著名历史人物。文中还讨论了关于脓毒症相关疾病的病因（微生物病原体）、发病机制（毒素和介质）以及治疗的早期描述和理论。