Piperi Evangelia, Rohrer Michael D, Pambuccian Stefan E, Koutlas Ioannis G
Department of Oral Pathology and Oral Medicine, Dental School, National and Kapodistrian University of Athens, Athens, Greece.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 May;107(5):685-90. doi: 10.1016/j.tripleo.2008.12.046. Epub 2009 Mar 9.
Recent literature suggests that giant cell angiofibroma (GCAF) is a variant of solitary fibrous tumor (SFT) and not just a related lesion. Herein we present a case of apparent SFT with giant cells, including floret cells and focal pseudovascular areas, which are defining features of GCAF. The tumor occurred in the tongue of an 84-year-old female and depicted an encapsulated, patternless spindle cell proliferation in a fibromyxoid stroma with focal dense collagenous areas and scattered floret-type multinucleated giant cells seen primarily in the periphery, as well as pseudovascular spaces, numerous capillaries, and hemangiopericytomalike areas. Immunohistochemical investigation revealed positive staining for CD34 and positive immunoreaction for estrogen and progesterone receptors. We support the present notion that GCAF is a histologic subtype of SFT.
近期文献表明，巨细胞血管纤维瘤（GCAF）是孤立性纤维性肿瘤（SFT）的一种变体，而不仅仅是一种相关病变。在此，我们报告一例具有巨细胞的明显SFT病例，包括小花细胞和局灶性假血管区域，这些是GCAF的特征性表现。该肿瘤发生于一名84岁女性的舌部，表现为在纤维黏液样基质中呈包膜完整、无特定结构的梭形细胞增生，伴有局灶性致密胶原区域，散在的小花型多核巨细胞主要见于周边，还有假血管腔隙、大量毛细血管及血管外皮细胞瘤样区域。免疫组织化学检查显示CD34染色阳性，雌激素和孕激素受体免疫反应阳性。我们支持目前认为GCAF是SFT组织学亚型的观点。
