通过单调点变换，利用增强型激光散斑对比分析（eLASCA）对脑血流进行成像。
Imaging the cerebral blood flow with enhanced laser speckle contrast analysis (eLASCA) by monotonic point transformation.
作者信息
Miao Peng, Li Minheng, Fontenelle Hugues, Bezerianos Anastasios, Qiu Yihong, Tong Shanbao
机构信息
Department of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
出版信息
IEEE Trans Biomed Eng. 2009 Apr;56(4):1127-33. doi: 10.1109/TBME.2008.2006855. Epub 2008 Oct 31.
Laser speckle contrast analysis (LASCA) has been demonstrated as a full-field method for imaging the cerebral blood flow (CBF). However, conventional LASCA is limited to extremely low dynamic range because of the ambient background field, dark current, and other anomalies in the circuits of a charge-coupled device camera, which makes it difficult to analyze the spatiotemporal variabilities in CBF. In this study, we proposed an enhanced LASCA (eLASCA) method to improve the dynamic range of LASCA based on monotonic point transformation. In investigating the influence of moderate hypothermia (32+/-0.5 degrees C) on capillary CBF change, eLASCA presented much more significant decrease of relative CBF than LASCA (hypothermia: 189% versus 137%, postrewarming: 151% versus 119%). Statistically, eLASCA resulted in a higher confidence degree (p=0.009) of CBF change after the rewarming than LASCA (p=0.013). In addition, eLASCA greatly improves the CBF visualization, which is very helpful in demonstrating the details of CBF change.
激光散斑对比分析（LASCA）已被证明是一种用于脑血流（CBF）成像的全场方法。然而，由于环境背景场、暗电流以及电荷耦合器件相机电路中的其他异常情况，传统的LASCA动态范围极低，这使得分析CBF的时空变化变得困难。在本研究中，我们提出了一种基于单调点变换的增强型LASCA（eLASCA）方法，以提高LASCA的动态范围。在研究中度低温（32±0.5摄氏度）对毛细血管CBF变化的影响时，eLASCA显示相对CBF的下降比LASCA更为显著（低温时：189%对137%，复温后：151%对119%）。从统计学角度来看，复温后eLASCA导致CBF变化的置信度（p=0.009）高于LASCA（p=0.013）。此外，eLASCA极大地改善了CBF的可视化效果，这对于展示CBF变化的细节非常有帮助。
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