Patel Shruti, Alangaden George J, Lum Larry G, Cronin Simon M, Abidi Muneer H, Dieterle Natalie, Ibrahim Rami B
Wayne State University, Detroit, MI, USA.
J Oncol Pharm Pract. 2009 Sep;15(3):187-9. doi: 10.1177/1078155208101122. Epub 2009 Mar 10.
A hematopoietic stem cell transplant patient with a history of immediate drug hypersensitivity reaction to micafungin was considered for a caspofungin trial. A caspofungin intradermal skin test was performed. The result was positive, suggesting the presence of cross-reactivity and that the cyclic peptide nucleus chemical structure shared between echinocandins is the site of IgE recognition. It is recommended to avoid challenging patients with history of immediate hypersensitivity to one echinocandin with another.
一名对米卡芬净有速发型药物过敏反应病史的造血干细胞移植患者被考虑进行卡泊芬净试验。进行了卡泊芬净皮内皮肤试验。结果为阳性，提示存在交叉反应，且棘白菌素之间共有的环肽核化学结构是IgE识别位点。建议避免对有对一种棘白菌素速发型过敏史的患者使用另一种棘白菌素进行激发试验。
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