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胸部的伴有嗜酸性粒细胞增多的巨大血管淋巴样增生症

Giant angiolymphoid hyperplasia with eosinophilia on the chest.

作者信息

Trindade Felicidade, Haro Rosario, Requena Luis

机构信息

Department of Dermatology, Hospital dos Capuchos, Lisbon, Portugal.

出版信息

J Cutan Pathol. 2009 Apr;36(4):493-6. doi: 10.1111/j.1600-0560.2008.01066.x.

Abstract

Angiolymphoid hyperplasia with eosinophilia is a rare vascular proliferation characterized by single or multiple purplish, brownish papules and subcutaneous nodules, sometimes associated with pain or pruritus. This rare benign process occurs with a female predominance. Approximately 85% of the lesions occur in the skin of the head and neck; most of them are around the ear or on the forehead or scalp. Whether angiolymphoid hyperplasia with eosinophilia represents a benign neoplasm or an unusual reaction to varied stimuli, including trauma, the etiology remains unclear. Histopathologically, the lesions consist of a proliferation of blood vessels of variable size lined by large epithelioid endothelial cells and a variable inflammatory infiltrate of lymphocytes and eosinophils, sometimes with lymphoid follicle formation. The lesion is benign but may be persistent and is difficult to eradicate. We report on a case of a 58-year-old Caucasian man who presented a purplish pink dome-shaped tumor of size up to 8 cm in diameter located on the chest. We emphasize this case considering the unusual dimensions of the lesion (8 cm diameter) and the atypical location on the chest.

摘要

嗜酸性粒细胞增多性血管淋巴样增生是一种罕见的血管增生性疾病,其特征为单个或多个紫色、褐色丘疹及皮下结节,有时伴有疼痛或瘙痒。这种罕见的良性病变女性多见。约85%的病变发生于头颈部皮肤;大多数位于耳部周围、前额或头皮。嗜酸性粒细胞增多性血管淋巴样增生究竟是一种良性肿瘤还是对包括创伤在内的多种刺激的异常反应,其病因尚不清楚。组织病理学上,病变由大小不一的血管增生组成,血管内衬大的上皮样内皮细胞,并伴有淋巴细胞和嗜酸性粒细胞的不同程度炎症浸润,有时可见淋巴滤泡形成。该病变为良性,但可能持续存在且难以根除。我们报告一例58岁白种男性病例,其胸部出现一个直径达8 cm的紫粉色圆顶状肿瘤。考虑到病变的异常大小(直径8 cm)及胸部的非典型部位,我们对该病例予以强调。

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