自身免疫性重症肌无力中 HLA - A 与胸腺瘤的关联。

Association of HLA-A in autoimmune myasthenia gravis with thymoma.

作者信息

Vandiedonck Claire, Raffoux Colette, Eymard Bruno, Tranchant Christine, Dulmet Elisabeth, Krumeich Sophie, Gajdos Philippe, Garchon Henri-Jean

机构信息

Inserm U and Université Paris Descartes, Institut Cochin, Department of Immunology, France.

出版信息

J Neuroimmunol. 2009 May 29;210(1-2):120-3. doi: 10.1016/j.jneuroim.2009.02.004. Epub 2009 Mar 10.

DOI:10.1016/j.jneuroim.2009.02.004

PMID:19278738

Abstract

We investigated an association of the HLA-A locus in 78 French Caucasian patients with autoimmune myasthenia gravis (MG) and thymic epithelial tumours. The largest effect was a protection associated with HLA-A02 in MG patients with a B2 type thymoma (OR=0.323, 95% CI: 0.113-0.756, P=0.00041). The frequency of HLA-A25 was also increased in the whole group of patients (OR=3.62, 95% CI: 1.62-7.08, P=0.0041). Our findings emphasise the interest of the histological classification in the genetic study of thymomas.

摘要

我们对78名患有自身免疫性重症肌无力（MG）和胸腺上皮肿瘤的法国白种人患者的HLA - A基因座进行了研究。最大的影响是，在患有B2型胸腺瘤的MG患者中，HLA - A02具有保护作用（OR = 0.323，95%置信区间：0.113 - 0.756，P = 0.00041）。在整个患者组中，HLA - A25的频率也有所增加（OR = 3.62，95%置信区间：1.62 - 7.08，P = 0.0041）。我们的研究结果强调了组织学分类在胸腺瘤遗传学研究中的重要性。