van Wijk A J, Tan S P K
Uit de afdeling Sociale Tandheelkunde en Voorlichtingskunde van het Academisch Centrum Tandheelkunde Amsterdam.
Ned Tijdschr Tandheelkd. 2009 Feb;116(2):63-7.
A genetic or developmental disorder can be the basis for the failure of a normal dental development, resulting in the absence of 1 or more teeth. For genetic research or the development of a plan of treatment, it is important to determine whether certain patterns of dental agenesis are more common than others. In the present article a new method is described where unique values are assigned to certain patterns of tooth agenesis. Using the idea of binary arithmetic, the absence or presence of teeth are represented by 1 and 0, and translated into corresponding unique values, the 'tooth agenesis code' (TAC). This procedure has advantages over existing methods in that it allows for easier data analysis, can contribute to genetic research into the aetiology of tooth agenesis and enables researchers to communicate unequivocally the phenotypes of their studied case. It can also be used in other areas of oral pathology that require pattern recognition.
遗传或发育障碍可能是正常牙齿发育失败的原因,导致一颗或多颗牙齿缺失。对于基因研究或治疗方案的制定,确定某些牙齿发育不全模式是否比其他模式更常见很重要。在本文中,描述了一种新方法,为某些牙齿发育不全模式赋予唯一值。利用二进制算法的概念,牙齿的缺失或存在用1和0表示,并转换为相应的唯一值,即“牙齿发育不全代码”(TAC)。该程序比现有方法具有优势,因为它便于数据分析,有助于对牙齿发育不全病因的基因研究,并使研究人员能够明确传达所研究病例的表型。它还可用于其他需要模式识别的口腔病理学领域。