Greenwood D, O'Grady F
J Med Microbiol. 1977 May;10(2):255-9. doi: 10.1099/00222615-10-2-255.
The activities against a strain of Escherichia coli of polymyxin B, colistin (polymyxin E) and their sulphomethyl derivatives sulphomyxin and colistin sulphomethate have been examined in an in-vitro model of the urinary bladder under conditions similar to those that may operate in the therapeutic situation. In the dynamic conditions of the model, polymyxins exhibited a reduced activity against E. coli in comparison with activity against exponentially growing cultures in a static system. Nevertheless, long-term suppression of bacterial growth was achieved with levels of polymyxin B and colistin that can be attained during therapy, whereas sulphomethylpolymyxins had little effect on bacterial growth even on prolonged exposure.
在与治疗情况相似的条件下，利用膀胱体外模型研究了多粘菌素B、粘菌素（多粘菌素E）及其磺甲基衍生物磺粘菌素和粘菌素甲磺酸盐对一株大肠杆菌的活性。在该模型的动态条件下，与在静态系统中对指数生长培养物的活性相比，多粘菌素对大肠杆菌的活性有所降低。然而，在治疗期间能够达到的多粘菌素B和粘菌素水平可实现对细菌生长的长期抑制，而磺甲基多粘菌素即使长时间接触对细菌生长也几乎没有影响。
