Chatterjee T, Ortak J, Akin I, Adolph E, Kleinfeldt T, Kische S, Nienaber C A, Ince H
Abteilung für Kardiologie, Universitätsklinikum Rostock (D) und Herzzentrum Hirslanden Zentralschweiz, Klinik St. Anna, Luzern, Germany.
Praxis (Bern 1994). 2009 Mar 18;98(6):321-9. doi: 10.1024/1661-8157.98.6.321.
The aim of regenerative medicine is the reconstitution of the physiological structure of critically damaged organs. Bone marrow derived stem cells (BMDCs) show promising therapeutic potential. BMDCs are already used in oncology and are ideally suited for regenerative medicine due to their regenerative potential and safety profile. A variety of cells have been contemplated in cardiology, and there is emerging preclinical and clinical data on the feasibility and safety of different cell lines in the setting of acute myocardial infarction and chronic heart failure. In this review, the various concepts and cells will be discussed in further detail.
再生医学的目标是重建严重受损器官的生理结构。骨髓来源的干细胞(BMDCs)显示出有前景的治疗潜力。BMDCs已用于肿瘤学领域,并且由于其再生潜力和安全性,非常适合再生医学。心脏病学领域已经考虑了多种细胞,并且在急性心肌梗死和慢性心力衰竭的情况下,关于不同细胞系的可行性和安全性的临床前和临床数据正在不断涌现。在这篇综述中,将更详细地讨论各种概念和细胞。