Cilip Christopher M, Jarow Jonathan P, Fried Nathaniel M
Department of Physics and Optical Science, University of North Carolina at Charlotte, Charlotte, North Carolina 28223-0001, USA.
Lasers Surg Med. 2009 Mar;41(3):203-7. doi: 10.1002/lsm.20744.
Male sterilization (vasectomy) is more successful, safer, less expensive, and easier to perform than female sterilization (tubal ligation). However, female sterilization is more popular, primarily due to male fear of vasectomy complications (incision, bleeding, infection, and scrotal pain). The development of a completely noninvasive vasectomy technique may eliminate these concerns.
Ytterbium fiber laser radiation with a wavelength of 1,075 nm, average power of 11.7 W, 1-second pulse duration, 0.5 Hz pulse rate, and 3-mm-diameter spot was synchronized with cryogen cooling of the scrotal skin surface in canine tissue for a treatment time of 60 seconds.
Vas thermal lesion dimensions measured 2.0+/-0.3 mm diameter by 3.0+/-0.9 mm length, without evidence of skin damage. The coagulated vas bursting pressure measured 295+/-72 mm Hg, significantly higher than typical vas ejaculation pressures of 136+/- 29 mm Hg.
Noninvasive thermal coagulation and occlusion of the vas was produced in an ex vivo canine tissue model. However, chronic in vivo animal studies will be necessary to optimize the laser/cooling treatment parameters and confirm long-term vas occlusion with absence of sperm in the ejaculate, before clinical application.
男性绝育术(输精管切除术)比女性绝育术(输卵管结扎术)更成功、更安全、成本更低且操作更简便。然而,女性绝育术更受欢迎,主要是因为男性担心输精管切除术的并发症(切口、出血、感染和阴囊疼痛)。一种完全无创的输精管切除技术的开发可能会消除这些担忧。
在犬类组织中,将波长为1075nm、平均功率为11.7W、脉冲持续时间为1秒、脉冲频率为0.5Hz且光斑直径为3mm的镱光纤激光辐射与阴囊皮肤表面的低温冷却同步,治疗时间为60秒。
输精管热损伤尺寸为直径2.0±0.3mm,长度3.0±0.9mm,无皮肤损伤迹象。凝固的输精管破裂压力为295±72mmHg,显著高于典型的输精管射精压力136±29mmHg。
在体外犬类组织模型中实现了输精管的无创热凝固和闭塞。然而,在临床应用之前,需要进行慢性体内动物研究,以优化激光/冷却治疗参数,并确认射精中无精子的长期输精管闭塞情况。