急性酒精暴露的体外和体内模型。
In vitro and in vivo models of acute alcohol exposure.
作者信息
Dolganiuc Angela, Szabo Gyongyi
机构信息
Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, United States.
出版信息
World J Gastroenterol. 2009 Mar 14;15(10):1168-77. doi: 10.3748/wjg.15.1168.
Abstract
Alcohol abuse is a global problem due to the financial burden on society and the healthcare system. While the harmful health effects of chronic alcohol abuse are well established, more recent data suggest that acute alcohol consumption also affects human wellbeing. Thus, there is a need for research models in order to fully understand the effect of acute alcohol abuse on different body systems and organs. The present manuscript summarizes the interdisciplinary advantages and disadvantages of currently available human and non-human models of acute alcohol abuse, and identifies their suitability for biomedical research.
摘要
由于对社会和医疗保健系统造成经济负担，酒精滥用是一个全球性问题。虽然慢性酒精滥用对健康的有害影响已得到充分证实，但最新数据表明，急性饮酒也会影响人类健康。因此，需要研究模型以便全面了解急性酒精滥用对不同身体系统和器官的影响。本手稿总结了目前可用的急性酒精滥用人类和非人类模型的跨学科优缺点，并确定了它们在生物医学研究中的适用性。
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