Wiersema Brent M, Scheid D Kevin, Psaradellis Telly
Great Lakes Orthopedic Center, Munson Medical Center, 4045 W Royal Dr, Traverse City, MI 49684, USA.
Orthopedics. 2008 Mar;31(3):274. doi: 10.3928/01477447-20080301-43.
Gas gangrene or clostridial myonecrosis is a rare, life threatening infection of the muscle that is typically associated with recent surgery or trauma. It usually affects older individuals who suffer from vascular insufficiency or who are immunocompromised. The typical pathogen is Clostridium perfringens. Atraumatic gas gangrene caused by Clostridium septicum is less common and has a unique association with colon cancer. This condition aggressively spreads through the muscular tissue and often culminates in septic shock. Fatality occurs within 48 hours if left untreated yet, despite emergent treatment the mortality rate is >50% without any comorbidities. Given the propensity to occur in the extremities the orthopedic surgeon must be familiar with its presentation, diagnosis, and treatment. This article presents a case of a 16-year-old girl who presented to the emergency room with an 18-hour history of malaise and progressive right arm discomfort and swelling. The identification and emergent treatment of necrotizing soft tissue infections is important and often falls on the orthopedic surgeon, especially when isolated to the extremities. Subtle initial presentation and rapid progression of the infection are classic findings of necrotizing soft tissue infections, particularly with clostridial myonecrosis and necrotizing fasciitis. Clostridium myonecrosis is a rare orthopedic condition with high mortality. Early diagnosis and debridement is imperative. A team approach to managing these patients postoperatively is necessary. The use of hyperbaric oxygen can be considered, however, it may not be readily available and its use is unproven in human studies. Due to its high mortality, one should err on the side of more aggressive resective/ablative surgery.
气性坏疽或梭菌性肌坏死是一种罕见的、危及生命的肌肉感染,通常与近期手术或创伤有关。它通常影响患有血管功能不全或免疫功能低下的老年人。典型病原体是产气荚膜梭菌。由败血梭菌引起的非创伤性气性坏疽较少见,且与结肠癌有独特关联。这种情况会在肌肉组织中迅速扩散,常导致感染性休克。若不治疗,48小时内就会死亡,然而,即便进行紧急治疗,在没有任何合并症的情况下死亡率仍超过50%。鉴于其好发于四肢,骨科医生必须熟悉其临床表现、诊断和治疗方法。本文介绍了一名16岁女孩的病例,她因18小时的不适、右臂逐渐加重的疼痛和肿胀而被送往急诊室。坏死性软组织感染的识别和紧急治疗很重要,且常常落在骨科医生身上,尤其是当感染局限于四肢时。感染初期表现隐匿且进展迅速是坏死性软组织感染的典型特征,特别是梭菌性肌坏死和坏死性筋膜炎。梭菌性肌坏死是一种罕见的骨科疾病,死亡率很高。早期诊断和清创至关重要。术后需要采用团队协作的方式来管理这些患者。可以考虑使用高压氧,然而,高压氧可能不易获得,且其在人体研究中的效果尚未得到证实。鉴于其高死亡率,手术应采取更积极的切除/清创方式。