母乳喂养医学学会2008年创始人讲座：母乳喂养——母婴之间的宫外联系。
Academy of Breastfeeding Medicine founder's lecture 2008: breastfeeding--an extrauterine link between mother and child.
作者信息
Rautava Samuli, Walker W Allan
机构信息
Developmental Gastroenterology Laboratory, Division of Pediatric Gastroenterology, Massachusetts General Hospital for Children, Charlestown, Massachusetts, USA.
出版信息
Breastfeed Med. 2009 Mar;4(1):3-10. doi: 10.1089/bfm.2009.0004.
Abstract
In addition to a near-optimal combination of nutrients for the growing infant, breastmilk contains a wide array of bioactive molecules that are known to protect the infant against infectious disease and modulate the composition of the indigenous intestinal microbiota. A growing number of factors that modulate the infant's immunophysiology have also been identified in breastmilk. We suggest that this early immunomodulation via breastmilk is vital for infant health and may explain the epidemiological data indicating that breastmilk reduces the risk of immunoinflammatory conditions in infancy and also later in life. The body of scientific data regarding the role of transforming growth factor-beta in breastmilk in enhancing healthy immune maturation and reducing the risk of disease is reviewed in this article.
摘要
除了为成长中的婴儿提供近乎最佳的营养组合外，母乳还含有大量生物活性分子，已知这些分子可保护婴儿免受传染病侵害，并调节肠道内原生微生物群的组成。母乳中还发现了越来越多调节婴儿免疫生理学的因素。我们认为，通过母乳进行的这种早期免疫调节对婴儿健康至关重要，这或许可以解释流行病学数据，即母乳可降低婴儿期及以后患免疫炎症性疾病的风险。本文综述了关于母乳中转化生长因子-β在促进健康免疫成熟和降低疾病风险方面作用的科学数据。
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