Zuppa Athena F, Mondick John T, Davis Lisa, Cohen David
Division of Clinical Pharmacology and Therapeutics, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Am J Ther. 2009 Mar-Apr;16(2):143-6. doi: 10.1097/MJT.0b013e31818071df.
Although ketorolac is commonly used as an analgesic in the pediatric population, there is no information on the pharmacokinetics of ketorolac available for children less than 6 months of age. The objective of this analysis was to construct a population pharmacokinetic model to describe ketorolac disposition in young children. Three neonates and 9 infants, median (range) age 0.4-32 weeks, were administered with 0.5 mg/kg of ketorolac. The data were best described by a 2-compartment model, with an allometric expression to describe body weight effects on clearance. Estimated parameters were clearance [2.8 mL x min(-1) x (kg(0.75))(-1)], intercompartmental clearance (11.5 mL/min), volume of distribution of the central compartment (535 mL), and volume of distribution of the peripheral compartment (322 mL). The clearance values in these neonates and younger group of infants are greater than that reported for older children and adults.
尽管酮咯酸在儿科人群中常用作镇痛药，但对于6个月以下儿童，尚无酮咯酸的药代动力学信息。本分析的目的是构建一个群体药代动力学模型，以描述幼儿体内酮咯酸的处置情况。对3名新生儿和9名婴儿（年龄中位数[范围]为0.4 - 32周）给予0.5 mg/kg的酮咯酸。数据用二室模型描述最佳，并用异速生长表达式描述体重对清除率的影响。估计参数为清除率[2.8 mL×min⁻¹×(kg⁰.⁷⁵)⁻¹]、隔室间清除率（11.5 mL/min）、中央室分布容积（535 mL）和外周室分布容积（322 mL）。这些新生儿和较小婴儿组的清除率值高于大龄儿童和成人的报道值。
