阿拉文德眼科医院白内障术后眼内炎的发病率:采用标准化消毒和预防方案的42000多例连续病例的结果
Incidence of post-cataract endophthalmitis at Aravind Eye Hospital: outcomes of more than 42,000 consecutive cases using standardized sterilization and prophylaxis protocols.
作者信息
Ravindran Ravilla D, Venkatesh Rengaraj, Chang David F, Sengupta Sabyasachi, Gyatsho Jamyang, Talwar Badrinath
机构信息
Aravind Eye Hospital, Post Graduate Institute of Ophthalmology, Pondicherry, India.
出版信息
J Cataract Refract Surg. 2009 Apr;35(4):629-36. doi: 10.1016/j.jcrs.2009.01.002.
PURPOSE
To report the incidence of postoperative endophthalmitis at a high-volume eye hospital in southern India using a modified cost-effective sterilization protocol.
SETTING
Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Pondicherry, India.
METHODS
In this retrospective observational series at a single eye hospital, records of patients who had cataract surgery using a modified sterilization protocol from January 2007 through August 2008 and developed postoperative endophthalmitis within the first 3 postoperative months were drawn from a computerized database. The patient's socioeconomic status, the surgeon's experience, and the type of cataract procedure performed were analyzed as possible risk factors using the chi-square test/Fischer exact test.
RESULTS
During the study period, 42426 cataract surgeries were performed. From these, 38 cases of presumed postoperative endophthalmitis were identified (incidence 0.09%). Thirty-five of the 38 cases were in the manual large- and small-incision extracapsular cataract extraction (ECCE) group, which had a statistically higher rate than the phacoemulsification group (P = .016). There was no statistical difference in the endophthalmitis rates between private patients and charity patients for either surgical method (manual ECCE or phacoemulsification).
CONCLUSIONS
The modified sterilization and asepsis protocol adopted to facilitate high-volume cataract surgery in a clinical setting appeared to be safe and effective in preventing postsurgical endophthalmitis. Despite a 3:1 ratio of manual ECCE to phacoemulsification and the elimination of certain traditional sterilization practices, the rate of endophthalmitis in this generally underserved patient population with multiple risk factors for infection was comparable to that reported in other modern settings.
目的
采用改良的具有成本效益的消毒方案,报告印度南部一家大型眼科医院术后眼内炎的发生率。
背景
印度本地治里市阿拉文眼科医院及眼科研究生学院。
方法
在这家单中心眼科医院开展的回顾性观察系列研究中,从计算机数据库中提取2007年1月至2008年8月期间采用改良消毒方案进行白内障手术且在术后前3个月内发生术后眼内炎的患者记录。使用卡方检验/费舍尔精确检验分析患者的社会经济状况、外科医生的经验以及所施行的白内障手术类型等可能的危险因素。
结果
在研究期间,共进行了42426例白内障手术。其中,确诊为术后疑似眼内炎的病例有38例(发生率为0.09%)。38例病例中有35例属于手法大切口及小切口白内障囊外摘除术(ECCE)组,该组发生率在统计学上高于超声乳化白内障吸除术组(P = 0.016)。对于两种手术方式(手法ECCE或超声乳化白内障吸除术),自费患者和慈善患者的眼内炎发生率均无统计学差异。
结论
在临床环境中为便于开展大量白内障手术而采用的改良消毒和无菌方案在预防术后眼内炎方面似乎是安全有效的。尽管手法ECCE与超声乳化白内障吸除术的比例为3:1,且摒弃了某些传统消毒做法,但在这个普遍医疗服务不足且存在多种感染危险因素的患者群体中,眼内炎发生率与其他现代环境下报告的发生率相当。