Gibson P H, Croal B L, Cuthbertson B H, Gibson G, Jeffrey R R, Buchan K G, El-Shafei H, Hillis G S
Department of Cardiology, University of Aberdeen and Aberdeen Royal Infirmary, Aberdeen, UK.
Heart. 2009 May;95(10):793-8. doi: 10.1136/hrt.2008.149849. Epub 2009 Mar 19.
To determine the effects of socio-economic status (SES) on the outcome of coronary artery bypass grafting (CABG).
Prospective cohort study.
Regional cardiac surgical unit.
1994 consecutive patients undergoing non-emergency CABG.
SES was determined from the patient's postcode using Carstairs tables. The primary end-point was all-cause mortality at 30 days.
There were 50 deaths (2.5%) within 30 days of surgery. A higher Carstairs score demonstrated a trend towards increased 30-day mortality (odds ratio (OR) 1.09 per unit, 95% CI 1.00 to 1.20, p = 0.06). In a backward conditional model, including other predictors of early mortality, Carstairs scores were independently predictive (OR 1.12 per unit, 95% CI 1.01 to 1.24, p = 0.02). In a model including only Carstairs scores and the EuroSCORE, both were independent predictors of this outcome (OR for Carstairs score 1.11 per unit, 95% CI 1.00 to 1.22, p = 0.04). The 30-day mortality increases in each quartile of Carstairs scores, with patients in quartile 4 (most deprived) at significantly higher risk compared with quartile 1 (uncorrected OR 2.53 per unit, 95% CI 1.04 to 6.15; OR corrected for EuroSCORE, 2.56 per unit, 95% CI 1.03 to 6.34, p = 0.04 for both). Similarly, patients in the least affluent quartile were twice as likely to suffer a serious complication as those in the most affluent quartile (OR 2.14 per unit, 95% CI 1.32 to 3.46, p = 0.002). This increased risk was also independent of the EuroSCORE.
Lower SES is associated with a poorer early outcome following CABG and is independent of other recognised risk factors.
确定社会经济地位(SES)对冠状动脉旁路移植术(CABG)结局的影响。
前瞻性队列研究。
地区心脏外科病房。
1994例连续接受非急诊CABG的患者。
使用卡斯尔斯量表根据患者邮政编码确定SES。主要终点为30天全因死亡率。
术后30天内有50例死亡(2.5%)。较高的卡斯尔斯评分显示出30天死亡率增加的趋势(每单位优势比(OR)为1.09,95%可信区间为1.00至1.20,p = 0.06)。在一个向后条件模型中,纳入早期死亡率的其他预测因素后,卡斯尔斯评分具有独立预测性(每单位OR为1.12,95%可信区间为1.01至1.24,p = 0.02)。在一个仅包含卡斯尔斯评分和欧洲心脏手术风险评估系统(EuroSCORE)的模型中,两者都是该结局的独立预测因素(卡斯尔斯评分每单位OR为1.11,95%可信区间为1.00至1.22,p = 0.04)。卡斯尔斯评分的每个四分位数中30天死亡率均升高,与第一四分位数(最不贫困)的患者相比,第四四分位数(最贫困)的患者风险显著更高(未校正的每单位OR为2.53,95%可信区间为1.04至6.15;校正EuroSCORE后的OR为每单位2.56,95%可信区间为1.03至6.34,两者p均 = 0.04)。同样,最不富裕四分位数的患者发生严重并发症的可能性是最富裕四分位数患者的两倍(每单位OR为2.14,95%可信区间为1.32至3.46,p = 0.002)。这种增加的风险也独立于EuroSCORE。
较低的SES与CABG术后较差的早期结局相关,且独立于其他公认的风险因素。