Travin Mark I
Department of Nuclear Medicine, Montefiore Medical Center, Bronx, NY 10467 2490, USA.
Cardiol Clin. 2009 May;27(2):311-27, Table of Contents. doi: 10.1016/j.ccl.2008.12.007.
Cardiac neuronal innervation plays an important role in normal cardiac function and is adversely affected in the presence of disease. In particular, radiotracer imaging of cardiac sympathetic function has been extensively investigated and not only provides a method of assessing the severity of disease but also has repeatedly been shown to be prognostically useful with a potential for helping to guide patient management. SPECT imaging of myocardial uptake of (123)I-mIBG, an analog of the sympathetic neurotransmitter norepinephrine, has been the most studied, but PET neurotracers, such as (11)C-HED, are also under investigation. The ability of cardiac neuronal imaging to visualize and measure underlying molecular processes should allow it to provide a perspective on cardiac disease that other testing modalities cannot.
心脏神经支配在正常心脏功能中起着重要作用，且在疾病状态下会受到不利影响。特别是，心脏交感神经功能的放射性示踪剂成像已得到广泛研究，它不仅提供了一种评估疾病严重程度的方法，而且多次被证明在预后方面具有重要价值，有可能帮助指导患者管理。心肌摄取作为交感神经递质去甲肾上腺素类似物的（123）I - mIBG的单光子发射计算机断层显像（SPECT）成像研究最多，但正电子发射断层显像（PET）神经示踪剂，如（11）C - HED，也在研究中。心脏神经成像可视化和测量潜在分子过程的能力应使其能够提供其他检测方式无法提供的关于心脏病的视角。
