通过印片细胞学对乳腺癌前哨淋巴结进行术中评估。
Intraoperative estimation of sentinel lymph nodes in breast cancer by imprint cytology.
作者信息
Limberis V, Romanidis C, Galazios G, Koutsougeras G, Papadopoulos N, Lambropoulou M, Simopoulos C
机构信息
Department of Obstetrics & Gynecology, Democritus University of Thrace, Greece.
出版信息
Eur J Gynaecol Oncol. 2009;30(1):85-7.
BACKGROUND
Frozen section biopsy has been widely used for intraoperative diagnosis and evaluation of sentinel lymph nodes, so a decision can be made regarding whether to perform axillary clearance during primary surgery. This study aims to discuss the reliability of a simpler and faster method - touch imprint cytology - in the interpretation of metastasis from breast cancer.
METHODS
A retrospective review of 41 sentinel lymph node biopsies from patients with breast cancer were examined by intraoperative imprint cytology using rapid Diff-Quick staining. Paraffin-embedded permanent sections were examined using hematoxylin and eosin stained sections from the sentinel lymph nodes in collaboration with the employment of an anti-cytokeratin antibody.
RESULTS
Sixteen of all sentinel nodes harbored metastases in the paraffin sections, of which all 16 were identified by imprint cytology (sensitivity 93%).
CONCLUSION
Touch imprint cytology is a fast and reliable alternative for intraoperative evaluation of sentinel lymph nodes in breast cancer patients.
背景
冰冻切片活检已广泛用于前哨淋巴结的术中诊断和评估，以便在初次手术时决定是否进行腋窝清扫。本研究旨在探讨一种更简单、快速的方法——触摸印片细胞学检查——在乳腺癌转移灶判读中的可靠性。
方法
对41例乳腺癌患者的前哨淋巴结活检进行回顾性研究，术中采用快速Diff-Quick染色法进行印片细胞学检查。前哨淋巴结石蜡包埋的永久切片采用苏木精-伊红染色，并联合使用抗细胞角蛋白抗体进行检查。
结果
所有前哨淋巴结中，石蜡切片有16个存在转移，其中印片细胞学检查均识别出这16个转移灶（敏感性93%）。
结论
触摸印片细胞学检查是乳腺癌患者前哨淋巴结术中评估的一种快速且可靠的替代方法。
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