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SLA系统因子命名法,2008年更新

Nomenclature for factors of the SLA system, update 2008.

作者信息

Ho C-S, Lunney J K, Ando A, Rogel-Gaillard C, Lee J-H, Schook L B, Smith D M

机构信息

Department of Pathology, University of Michigan, 1150 W. Medical Center Drive, Ann Arbor, MI 48109, USA.

出版信息

Tissue Antigens. 2009 Apr;73(4):307-15. doi: 10.1111/j.1399-0039.2009.01213.x.

Abstract

This report summarizes the new swine leukocyte antigen (SLA) allele sequences and haplotypes designated by the SLA Nomenclature Committee of the International Society for Animal Genetics. There have been 74 new SLA alleles, comprising 18 SLA-1 alleles, 11 SLA-2 alleles, six SLA-3 alleles, two SLA-6 alleles, one SLA-DRA allele, 20 SLA-DRB1 alleles, three SLA-DQA alleles and 13 SLA-DQB1 alleles. Twelve new SLA class I and four new class II haplotypes have also been designated. This is the first official update since the 2005 reports on the nomenclature for factors of the SLA class I and II systems. This report also summarizes recent updates to the Immunopolymorphism Database-Major Histocompatibility Complex (IPD-MHC) website (http://www.ebi.ac.uk/ipd/mhc/sla/). All information has now been integrated to the SLA section of the IPD-MHC database, which serves as the repository for maintaining a list of all recognized SLA genes and their allelic sequences.

摘要

本报告总结了国际动物遗传学会猪白细胞抗原(SLA)命名委员会指定的新SLA等位基因序列和单倍型。新的SLA等位基因有74个,包括18个SLA-1等位基因、11个SLA-2等位基因、6个SLA-3等位基因、2个SLA-6等位基因、1个SLA-DRA等位基因、20个SLA-DRB1等位基因、3个SLA-DQA等位基因和13个SLA-DQB1等位基因。还指定了12个新的SLA I类和4个新的II类单倍型。这是自2005年关于SLA I类和II类系统因子命名的报告以来的首次官方更新。本报告还总结了免疫多态性数据库-主要组织相容性复合体(IPD-MHC)网站(http://www.ebi.ac.uk/ipd/mhc/sla/)的最新更新情况。所有信息现已整合到IPD-MHC数据库的SLA部分,该数据库是维护所有已识别的SLA基因及其等位基因序列列表的储存库。

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