社区中抑郁症的家族性；与重度抑郁症的性别及表型的关联
Familiality of depression in the community; associations with gender and phenotype of major depressive disorder.
作者信息
Janzing J G E, de Graaf R, ten Have M, Vollebergh W A, Verhagen M, Buitelaar J K
机构信息
Department of Psychiatry, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
出版信息
Soc Psychiatry Psychiatr Epidemiol. 2009 Dec;44(12):1067-74. doi: 10.1007/s00127-009-0026-4. Epub 2009 Mar 25.
INTRODUCTION
Although associations between family history and depression have been shown in clinical patients, it is unknown if they also apply to subjects living in the community. The present study considers the relationship between family loading and depression phenotype characteristics in a large community-based sample.
METHOD
In a Dutch representative population sample of 7,076 individuals, lifetime diagnosis of depression was classified according to severity, course and age of onset. A family loading score of depression (FLSD) was computed by taking the proportion of the first-degree relatives for whom a history of depression was reported.
RESULTS
There was a strong association between FLSD and lifetime diagnosis of MDD. Severity, recurrence and early onset of depression were the specific phenotypic characteristics associated with familiality. The effects of FLSD and gender were independent.
CONCLUSION
Associations between family history and risk for depression in the community confirm those reported from clinical-based studies using direct interviewing of relatives. A stronger degree of familiality is associated with specific phenotypic characteristics of depression.
引言
尽管在临床患者中已显示家族史与抑郁症之间存在关联，但这些关联是否也适用于社区中的人群尚不清楚。本研究在一个基于社区的大样本中探讨家族负荷与抑郁表型特征之间的关系。
方法
在一个包含7076名个体的荷兰代表性人群样本中，根据严重程度、病程和发病年龄对抑郁症的终生诊断进行分类。通过计算报告有抑郁症病史的一级亲属的比例来计算抑郁症家族负荷评分（FLSD）。
结果
FLSD与重度抑郁症的终生诊断之间存在强烈关联。抑郁症的严重程度、复发和早发是与家族性相关的特定表型特征。FLSD和性别的影响是独立的。
结论
社区中家族史与抑郁症风险之间的关联证实了基于临床研究通过直接询问亲属所报告的结果。更强程度的家族性与抑郁症的特定表型特征相关。
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