血凝素 - 神经氨酸酶基因非翻译区在新城疫病毒复制和致病性中的作用
Role of untranslated regions of the hemagglutinin-neuraminidase gene in replication and pathogenicity of newcastle disease virus.
作者信息
Yan Yongqi, Rout Subrat N, Kim Shin-Hee, Samal Siba K
机构信息
Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland 20742, USA.
出版信息
J Virol. 2009 Jun;83(11):5943-6. doi: 10.1128/JVI.00188-09. Epub 2009 Mar 25.
Abstract
To determine the role of untranslated regions (UTRs) in replication and pathogenesis of Newcastle disease virus (NDV), we generated recombinant viruses with deletions in 5' and 3' UTRs of the HN mRNA. Deletion of any HN UTR did not noticeably affect in vitro replication of these viruses. However, complete deletion of the 5' UTR of the HN gene decreased the HN mRNA levels and HN protein contents in virus particles, resulting in attenuation of the virus in chickens. This indicates that the 5' UTR of HN mRNA plays an important role in replication and pathogenicity of NDV in vivo.
摘要
为了确定非翻译区（UTRs）在新城疫病毒（NDV）复制和发病机制中的作用，我们构建了在HN mRNA的5'和3' UTR中存在缺失的重组病毒。任何HN UTR的缺失对这些病毒的体外复制均无明显影响。然而，HN基因5' UTR的完全缺失降低了病毒粒子中HN mRNA水平和HN蛋白含量，导致病毒在鸡体内的毒力减弱。这表明HN mRNA的5' UTR在NDV体内复制和致病性中起重要作用。
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