Kurz Martin Wilhelm, Dekomien Gabriele, Nilsen Odd Bjarte, Larsen Jan Petter, Aarsland Dag, Alves Guido
Department of Neurology, Stavanger University Hospital, Stavanger, Norway.
J Geriatr Psychiatry Neurol. 2009 Sep;22(3):166-70. doi: 10.1177/0891988709332945. Epub 2009 Mar 25.
Apolipoprotein E gene alleles have been linked to various cardiovascular and neurodegenerative disorders. There have been conflicting reports of associations between Apolipoprotein E alleles and Parkinson disease and Parkinson disease dementia. To investigate the role of Apolipoprotein E alleles in Parkinson disease and Parkinson disease dementia, we have determined Apolipoprotein E genotypes in a group of patients with Parkinson disease (n = 95) and compared them with those of healthy control participants (n = 73). Additionally, in 64 longitudinally followed patients with Parkinson disease, the allele types were correlated to development and progression of dementia and to time from onset of Parkinson disease to dementia using multivariate and survival analyses. The Apolipoprotein E e4e4 genotype was more common in patients with Parkinson disease (7.4%) than in healthy controls (1.4%; P = .03). No significant associations between the Apolipoprotein E genotype and development and progression of dementia or time to dementia were found. More studies with larger Parkinson disease samples are warranted.
载脂蛋白E基因等位基因与多种心血管和神经退行性疾病有关。关于载脂蛋白E等位基因与帕金森病及帕金森病痴呆之间的关联，一直存在相互矛盾的报道。为了研究载脂蛋白E等位基因在帕金森病和帕金森病痴呆中的作用，我们确定了一组帕金森病患者（n = 95）的载脂蛋白E基因型，并将其与健康对照参与者（n = 73）的基因型进行比较。此外，在64例接受纵向随访的帕金森病患者中，使用多变量和生存分析将等位基因类型与痴呆的发生和进展以及从帕金森病发病到痴呆的时间进行关联分析。载脂蛋白E e4e4基因型在帕金森病患者中（7.4%）比在健康对照者中（1.4%；P = 0.03）更常见。未发现载脂蛋白E基因型与痴呆的发生和进展或发生痴呆的时间之间存在显著关联。有必要对更大样本的帕金森病患者进行更多研究。
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