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预防静脉血栓栓塞的关键文章和指南。

Key articles and guidelines for the prevention of venous thromboembolism.

作者信息

Dobesh Paul P, Wittkowsky Ann K, Stacy Zachary, Dager William E, Haines Stuart T, Lopez Larry M, Nutescu Edith, Phillips Katherine W, Trujillo Toby C, Vondracek Tom

机构信息

Department of Pharmacy Practice, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska 68198-6045, USA.

出版信息

Pharmacotherapy. 2009 Apr;29(4):410-58. doi: 10.1592/phco.29.4.410.

Abstract

Venous thromboembolism (VTE) is an important medical problem that affects millions of patients each year. With appropriate prophylaxis, many of these thromboembolic events can be prevented. Although strong evidence supporting VTE prophylaxis spans several decades, several large American and global registries have documented very poor use of appropriate prophylaxis. Because of increasing regulatory requirements, hospitals nationwide are in the process of developing documentation of appropriate VTE prophylaxis programs for both surgical and medical patients. A wide range of clinicians must understand what constitutes appropriate VTE prophylaxis in various patient populations. With the existence of numerous pharmacologic agents, abundance of data from major clinical trials, and several nationally recognized clinical guidelines, compiling the needed reference material to make evidence-based decisions on appropriate VTE prophylaxis can be difficult for clinicians. Therefore, we provide a bibliography of key articles and guidelines related to the prevention of VTE in various patient groups. We hope this compilation will serve as a resource for pharmacists, physicians, nurses, residents, and students responsible for the care of patients who may be at risk for VTE.

摘要

静脉血栓栓塞症(VTE)是一个重要的医学问题,每年影响数百万患者。通过适当的预防措施,许多此类血栓栓塞事件是可以预防的。尽管支持VTE预防的有力证据已有数十年,但美国和全球的几个大型登记处记录显示,适当预防措施的使用情况非常糟糕。由于监管要求不断提高,全国的医院正在为外科和内科患者制定适当的VTE预防方案文档。众多临床医生必须了解在不同患者群体中什么构成适当的VTE预防措施。鉴于存在众多药物、来自主要临床试验的大量数据以及多项全国认可的临床指南,临床医生很难汇编所需的参考资料来做出关于适当VTE预防的循证决策。因此,我们提供了一份与不同患者群体VTE预防相关的关键文章和指南的参考书目。我们希望这份汇编能成为负责护理可能有VTE风险患者的药剂师、医生、护士、住院医师和学生的资源。

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