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孕期草药产品的使用情况:患病率及预测因素

Herbal products use during pregnancy: prevalence and predictors.

作者信息

Moussally Krystel, Oraichi Driss, Bérard Anick

机构信息

Faculty of Pharmacy, University of Montreal, Quebec, Canada.

出版信息

Pharmacoepidemiol Drug Saf. 2009 Jun;18(6):454-61. doi: 10.1002/pds.1731.

Abstract

PURPOSES

(1) Measure the prevalence of herbal product (HP) use, alone, and concomitantly with prescribed medications during pregnancy, (2) identify the most frequently consumed HP during gestation and (3) determine predictors of HP use at the beginning of pregnancy, and during the third trimester.

METHODS

A questionnaire was mailed to 8505 women selected from the Quebec Pregnancy Registry which was created by the linkage of three administrative databases: RAMQ, Méd-Echo and ISQ. Women were eligible if they were continuously insured by the RAMQ drug plan for at least 12 months before the first day of gestation and during pregnancy, and if they gave birth to a live born between January 1998 and December 2003 in one of the Quebec's hospitals. Women with diabetes and psychoses, and women who delivered a baby with birth defects were selected first. Descriptive statistics and multivariate logistic regression models were used to analyse data.

RESULTS

Of the 3354 women (39%) who answered the questionnaire, and were included in the study, nine per cent used HP during pregnancy. 69% of users took at least one prescribed medication concomitantly. Chamomile, green tea, peppermint and flax were the most frequently HP used. Multivariate analyses showed that body mass index (BMI), multivitamin use and one to three prescribed medications used before pregnancy were predictors of HP use at the beginning of pregnancy; adherent women, smokers and users of HP prior to pregnancy were predictors of HP use during the third trimester.

CONCLUSION

HP use alone and concomitantly with prescribed medications during pregnancy is common, and needs to be addressed by health professionals.

摘要

目的

(1)测量孕期单独使用草药产品(HP)以及与处方药同时使用的情况;(2)确定孕期最常使用的HP;(3)确定怀孕初期和孕晚期使用HP的预测因素。

方法

向从魁北克妊娠登记处选取的8505名女性邮寄了一份问卷,该登记处由三个行政数据库(RAMQ、Méd-Echo和ISQ)链接创建。如果女性在妊娠第一天前及孕期连续参加RAMQ药物计划至少12个月,且于1998年1月至2003年12月期间在魁北克的某家医院分娩活产婴儿,则符合入选条件。首先选取患有糖尿病和精神病的女性以及分娩出有出生缺陷婴儿的女性。采用描述性统计和多变量逻辑回归模型分析数据。

结果

在回复问卷并纳入研究的3354名女性(39%)中,9%在孕期使用HP。69%的使用者同时服用至少一种处方药。洋甘菊、绿茶、薄荷和亚麻是最常使用的HP。多变量分析显示,体重指数(BMI)、服用多种维生素以及怀孕前使用一至三种处方药是怀孕初期使用HP的预测因素;坚持服药的女性、吸烟者以及怀孕前使用HP的人是孕晚期使用HP的预测因素。

结论

孕期单独使用HP以及与处方药同时使用的情况很常见,卫生专业人员需要对此加以关注。

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