大剂量静脉内和鞘内注射甲氨蝶呤治疗急性淋巴细胞白血病后出现的假性光敏反应和短暂性偏瘫。
False-photosensitivity and transient hemiparesis following high-dose intravenous and intrathecal methotrexate for treatment of acute lymphoblastic leukemia.
作者信息
Shah Nilay, Zambidis Elias T
机构信息
Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA.
出版信息
Pediatr Blood Cancer. 2009 Jul;53(1):103-5. doi: 10.1002/pbc.21896.
Abstract
We describe a patient who was treated with high-dose intravenous and intrathecal methotrexate for acute lymphoblastic leukemia, and who manifested a false photosensitivity reaction with no prior evidence of sun exposure. This patient later experienced delayed transient hemiparesis following methotrexate administration, although without long-term sequelae. The etiology of these events is obscure, but suggestive of a vasculitic or immune-mediated reaction to methotrexate.
摘要
我们描述了一名急性淋巴细胞白血病患者，该患者接受了大剂量静脉注射和鞘内注射甲氨蝶呤治疗，且出现了假性光敏反应，之前并无阳光照射史。该患者在使用甲氨蝶呤后出现了延迟性短暂性偏瘫，不过未留下长期后遗症。这些事件的病因尚不清楚，但提示可能是对甲氨蝶呤的血管炎或免疫介导反应。
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