对哥伦比亚西南部三个州（考卡山谷省、考卡省和纳里尼奥省）的17个Y染色体短串联重复序列进行遗传群体分析。
Genetic population analysis of 17 Y-chromosomal STRs in three states (Valle del Cauca, Cauca and Nariño) from Southwestern Colombia.
作者信息
Julieta Avila Sandra, Briceño Ignacio, Gómez Alberto
机构信息
Grupo de Genética Forense, Instituto Nacional de Medicina Legal y Ciencias Forenses, Calle 7A 12-61 Tercer piso, Bogotá, Colombia.
出版信息
J Forensic Leg Med. 2009 May;16(4):204-11. doi: 10.1016/j.jflm.2008.12.002. Epub 2009 Jan 17.
Seventeen Y-chromosomal (DYS19, DYS389 I/II, DYS390, DYS391, DYS392, DYS393, DYS438, DYS439, DYS437, DYS448, DYS456, DYS458, DYS635, YGATA-H4 and DYS385a/b) short tandem repeat (STR) polymorphic systems were typed in three South West Colombian populations: Valle (short term for Valle del Cauca), Cauca and Nariño. DYS385a/b showed the highest gene diversity in the three populations. A total of 287 different Y-chromosome haplotypes were observed in the 308 males analyzed, and the haplotype diversity among populations was 0.9977. The most frequent haplotype was observed only three times and only nineteen others were observed two times. The highest gene diversity was found in Valle and the lowest in Cauca. Analysis of molecular variance (AMOVA) revealed that variation is mainly within populations (99.1%) in agreement with previous results in European populations. In conclusion, these populations could be pooled together in order to create one "Colombian-Mestizo" database for forensic use.
在哥伦比亚西南部的三个人口群体（考卡山谷省的简称瓦莱、考卡和纳里尼奥）中，对17个Y染色体短串联重复序列（STR）多态系统（DYS19、DYS389 I/II、DYS390、DYS391、DYS392、DYS393、DYS438、DYS439、DYS437、DYS448、DYS456、DYS458、DYS635、YGATA - H4和DYS385a/b）进行了分型。DYS385a/b在这三个人口群体中显示出最高的基因多样性。在分析的308名男性中，共观察到287种不同的Y染色体单倍型，群体间的单倍型多样性为0.9977。最常见的单倍型仅被观察到3次，其他仅被观察到2次的单倍型只有19种。基因多样性在瓦莱最高，在考卡最低。分子方差分析（AMOVA）显示，变异主要存在于群体内部（99.1%），这与欧洲人群的先前结果一致。总之，这些群体可以合并在一起，以创建一个用于法医用途的“哥伦比亚混血”数据库。
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