Nakano M, Fujita T, Ohtani J, Kawata T, Kaku M, Motokawa M, Tsuka N, Hayashi H, Tanne K
Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, Japan.
J Dent Res. 2009 Mar;88(3):261-5. doi: 10.1177/0022034508329671.
Previous studies have indicated that an injured condyle during adolescence is a causative factor for reduced mandibular growth and resulting asymmetry of the mandible. The aim of this study was to examine the nature of mandibular growth after unilateral condylectomy and to elucidate the effects of mandibular advancement. Sixty growing mice were subjected to unilateral condylectomy, and then one-half of them underwent treatment with a functional appliance. After 4 wks, a unilateral condylectomy produced reduced growth of the mandible and a subsequent lateral shift to the affected side. However, reduced growth and a lateral shift of the mandible were eliminated by a functional appliance, and prominent regeneration of the condyle was also demonstrated. It was shown that mandibular advancement provides for the regeneration of cartilaginous tissues on injured condyles and recovery of reduced mandibular growth, leading to correction of the lateral shift of the mandible.
先前的研究表明,青春期髁突损伤是下颌骨生长减少及导致下颌骨不对称的一个致病因素。本研究的目的是探讨单侧髁突切除术后下颌骨生长的性质,并阐明下颌前伸的影响。60只生长中的小鼠接受单侧髁突切除术,然后其中一半用功能性矫治器进行治疗。4周后,单侧髁突切除术导致下颌骨生长减少,并随后向患侧发生侧方移位。然而,功能性矫治器消除了下颌骨生长减少和侧方移位,并且还证实了髁突有明显的再生。结果表明,下颌前伸可促进损伤髁突软骨组织的再生及恢复减少的下颌骨生长,从而纠正下颌骨的侧方移位。