Gerasimou George, Bostantjopoulou Sevasti, Gotzamani-Psarrakou Anna
2nd Laboratory of Nuclear Medicine, AHEPA University Hospital, Thessaloniki, P.C. 54124, Macedonia-Greece.
Hell J Nucl Med. 2009 Jan-Apr;12(1):79-83.
In this review article the significance of molecular imaging techniques, single photon emission tomography and positron emission tomography (SPET and PET), in the diagnosis and differential diagnosis of various types of dementia is described. A major part of this article is focused on molecular imaging in Alzheimer's disease where parietal, temporal and posterior cingulate cortex hypoperfusion and hypometabolism are the predominant findings in molecular imaging modalities. In cases of mild amnestic cognitive impairment, molecular SPET imaging can differentiate patients converting to Alzheimer's disease from non converters. Molecular SPET imaging with pre-synaptic dopamine receptors radioligand ((123)I-ioflupane or DaTSCAN), is the method of choice in order to differentiate Alzheimer's disease from Lewy body dementia. Finally, nuclear medicine procedures support the diagnosis in fronto-temporal and multi-infarct dementia.
在这篇综述文章中，描述了分子成像技术，即单光子发射断层扫描和正电子发射断层扫描（SPET和PET）在各类痴呆诊断及鉴别诊断中的意义。本文的主要部分聚焦于阿尔茨海默病的分子成像，其中顶叶、颞叶和后扣带回皮质灌注不足和代谢减退是分子成像模式的主要发现。在轻度遗忘性认知障碍病例中，分子SPET成像可区分将转变为阿尔茨海默病的患者和未转变者。使用突触前多巴胺受体放射性配体（（123）I-碘氟潘或DaTSCAN）的分子SPET成像，是区分阿尔茨海默病和路易体痴呆的首选方法。最后，核医学检查有助于额颞叶痴呆和多发梗死性痴呆的诊断。
