Hureau Christelle, Faller Peter
CNRS, LCC (Laboratoire de Chimie de Coordination), 205 route de Narbonne, F-31077 Toulouse, France.
Biochimie. 2009 Oct;91(10):1212-7. doi: 10.1016/j.biochi.2009.03.013. Epub 2009 Mar 28.
Metal ions are involved in Alzheimer's disease (AD) via their ability to induce aggregation of amyloidogenic peptide and production of Reactive Oxygen Species (ROS), two key events in the development of the pathology. Here, we review very recent results concerning the coordination of Cu(I) and Cu(II) ion to the amyloid-beta peptide, the one encountered in AD. Implications of these structural data for the redox chemistry of the Cu(I/II)-Abeta couple are discussed. The different pathways for the ROS generation by the Cu(I/II)-Abeta species are described. In the more relevant one, reduction of dioxygen is realized by a two-electron process involving two Cu(I) in close vicinity, while the production of the hydroxyl radical from hydrogen peroxide is less constrained. A brief summary of how the Abeta peptide is oxidised during the ROS production is also given. Lastly, the pro- vs. anti-oxidant properties of Abeta are commented on.
金属离子通过诱导淀粉样肽聚集和产生活性氧（ROS）参与阿尔茨海默病（AD），这是该病理发展过程中的两个关键事件。在此，我们综述了关于铜（I）和铜（II）离子与AD中出现的β-淀粉样肽配位的最新研究结果。讨论了这些结构数据对铜（I/II）-β-淀粉样肽对氧化还原化学的影响。描述了铜（I/II）-β-淀粉样肽物种产生ROS的不同途径。在更相关的途径中，通过涉及两个紧邻的铜（I）的双电子过程实现氧气的还原，而过氧化氢产生羟基自由基的过程限制较少。还简要总结了在ROS产生过程中β-淀粉样肽是如何被氧化的。最后，对β-淀粉样肽的促氧化和抗氧化特性进行了评论。
