来自白姜花（Ham. Ex Smith）根茎降血糖提取物的新型半日花烷二萜类化合物作为肠道α-葡萄糖苷酶抑制剂
New Labdane diterpenes as intestinal alpha-glucosidase inhibitor from antihyperglycemic extract of Hedychium spicatum (Ham. Ex Smith) rhizomes.
作者信息
Prabhakar Reddy P, Tiwari Ashok K, Ranga Rao R, Madhusudhana K, Rama Subba Rao V, Ali Amtul Z, Suresh Babu K, Madhusudana Rao J
机构信息
Natural Products Laboratory, Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500 607, India.
出版信息
Bioorg Med Chem Lett. 2009 May 1;19(9):2562-5. doi: 10.1016/j.bmcl.2009.03.045. Epub 2009 Mar 16.
Phytochemical investigation of antihyperglycemic extract of rhizomes of Hedychium spicatum led to the isolation of two new labdane type diterpenes 2, 3 along with seven known compounds (1, 4-9). Their structures were established on the basis of NMR (1D and 2D) and mass spectroscopic analysis. The new compound 2 displayed strong intestinal alpha-glucosidase inhibitory activity. Other compounds also displayed varying degree of intestinal alpha-glucosidase inhibitory potential.
对长穗姜根茎的降血糖提取物进行植物化学研究，从中分离出两种新的半日花烷型二萜类化合物2和3，以及七种已知化合物（1、4 - 9）。它们的结构通过核磁共振（一维和二维）和质谱分析得以确定。新化合物2表现出较强的肠道α - 葡萄糖苷酶抑制活性。其他化合物也表现出不同程度的肠道α - 葡萄糖苷酶抑制潜力。
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