Center for Preventive Doping Research; Institute of Biochemistry; German Sport University Cologne; Cologne Germany.
Organogenesis. 2008 Oct;4(4):264-71. doi: 10.4161/org.4.4.7286.
Doping and manipulation are undesirable companions of professional and amateur sport. Numerous adverse analytical findings as well as confessions of athletes have demonstrated the variety of doping agents and methods as well as the inventiveness of cheating sportsmen. Besides 'conventional' misuse of drugs such as erythropoietin and insulins, experts fear that therapeutics that are currently undergoing clinical trials might be part of current or future doping regimens, which aim for an increased functionality and performance or organs and tissues. Emerging drugs such as selective androgen receptor modulators (SARMs), hypoxia-inducible factor (HIF) complex stabilizers or modulators of muscle fiber calcium channels are considered relevant for current and future doping controls due to their high potential for misuse in sports.
兴奋剂和操纵是专业和业余体育的不良伴生物。众多不良的分析结果以及运动员的坦白表明，兴奋剂的种类和方法多种多样，作弊的运动员也很有创造力。除了像促红细胞生成素和胰岛素等“常规”药物的滥用之外，专家们还担心目前正在进行临床试验的治疗方法可能会成为当前或未来兴奋剂方案的一部分，这些方案旨在提高器官和组织的功能和性能。由于其在运动中被滥用的高潜力，新兴药物如选择性雄激素受体调节剂 (SARMs)、缺氧诱导因子 (HIF) 复合物稳定剂或肌纤维钙通道调节剂等被认为与当前和未来的兴奋剂控制有关。
