青少年闭合性颅脑创伤后遗症及吡拉西坦对其治疗的疗效

Sequelae of closed craniocerebral trauma and the efficacy of piracetam in its treatment in adolescents.

作者信息

Zavadenko N N, Guzilova L S

机构信息

Department of Neurology and Neurosurgery, Faculty of Pediatrics, Russian State Medical University, Moscow, Russia.

出版信息

Neurosci Behav Physiol. 2009 May;39(4):323-8. doi: 10.1007/s11055-009-9146-2.

DOI:10.1007/s11055-009-9146-2

PMID:19340573

Abstract

The efficacy of piracetam in treating the sequelae of moderate and severe closed craniocerebral trauma (CCT) in adolescents was evaluated in studies of 42 patients aged 12-18 years who had suffered CCT 1.5-5 years prior to the study. Adolescents of the experimental group (20 individuals) received piracetam (Nootropil) at doses of 40-50 mg/kg (daily daily 1600-2400 mg) for one month; patients of group 2 (22 individuals) served as controls. Piracetam was found to have positive therapeutic effects on impairments to higher mental (memory, attention, executive) and motor (coordination) functions and on measures of the speeds of cognitive and motor operations.

摘要

在一项研究中，对42名年龄在12至18岁之间的青少年进行了评估，这些青少年在研究前1.5至5年曾遭受中度和重度闭合性颅脑创伤（CCT），以评估吡拉西坦治疗青少年中度和重度闭合性颅脑创伤后遗症的疗效。实验组（20人）的青少年接受剂量为40 - 50mg/kg（每日1600 - 2400mg）的吡拉西坦（脑复康）治疗一个月；第2组（22人）的患者作为对照。结果发现，吡拉西坦对高级心理（记忆、注意力、执行功能）和运动（协调）功能障碍以及认知和运动操作速度指标具有积极的治疗作用。