[激光辅助孵化：鲁昂大学医院的结果]

[Laser assisted hatching: Rouen University Hospital outcomes].

作者信息

Blessmann-Roset J, Rives N, Clavier B, Milazzo J-P, Mazurier S, Mousset-Siméon N, Macé B

机构信息

EA 4308 spermatogenèse et qualité du gamète male, laboratoire de biologie de la reproduction, CECOS, CHU Charles-Nicolle, 1, rue de Germont, 76031 Rouen cedex, France.

出版信息

Gynecol Obstet Fertil. 2009 Apr;37(4):313-20. doi: 10.1016/j.gyobfe.2009.01.020. Epub 2009 Apr 5.

DOI:10.1016/j.gyobfe.2009.01.020

PMID:19346148

Abstract

OBJECTIVE

Despite technical progress in In Vitro Fertilisation (IVF) procedure, embryo implantation rate remains low. Assisted hatching has been proposed to facilitate natural embryo hatching and implantation.

PATIENTS AND METHODS

Our study has evaluated whether laser assisted hatching improves implantation, pregnancy and live birth rates in different cases. We studied retrospectively 143 IVF cycles concerning more than 38 years old women, 166 IVF cycles after two previous implantation failures and 180 frozen-thawed embryo transfers.

RESULTS

Population characteristics were comparable in hatched and control groups. Implantation, pregnancy and live birth rates in women more than 38 years old were comparable with or without assisted hatching. Concerning repeated implantation failures, even if implantation, pregnancy and live birth rates were higher in assisted hatching group (FIV or ICSI), the differences were not significant. After frozen-thawed embryo transfers, implantation rate was significantly better with assisted hatching (19.14% vs 8.84% [p=0.02]).

DISCUSSION AND CONCLUSION

Assisted hatching improves embryo implantation rate after frozen-thawed embryo transfer.

摘要

目的

尽管体外受精（IVF）技术取得了进展，但胚胎着床率仍然很低。有人提出辅助孵化以促进胚胎自然孵化和着床。

患者与方法

我们的研究评估了激光辅助孵化在不同情况下是否能提高着床率、妊娠率和活产率。我们回顾性研究了143个IVF周期，涉及年龄超过38岁的女性，166个IVF周期是在先前两次着床失败后进行的，以及180个冻融胚胎移植。

结果

孵化组和对照组的人群特征具有可比性。年龄超过38岁的女性，无论有无辅助孵化，其着床率、妊娠率和活产率均具有可比性。对于反复着床失败的情况，即使辅助孵化组（IVF或ICSI）的着床率、妊娠率和活产率较高，但差异并不显著。冻融胚胎移植后，辅助孵化的着床率明显更好（19.14%对8.84%[p = 0.02]）。