Lacy Brian E, Edwards Susan, Paquette Lisa, Weiss Julia, Kelley Maurice L, Ornvold Kim
Division of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA.
J Clin Gastroenterol. 2009 Jul;43(6):514-9. doi: 10.1097/MCG.0b013e31818fba38.
To prospectively evaluate the tolerability and clinical utility of the Bravo pH capsule in children.
Acid reflux is common in children, and pH testing can be used to correlate acid exposure with symptom expression. The tolerability and clinical utility of the Bravo capsule in children has not been prospectively evaluated.
This was a prospective, open-label trial conducted at an academic medical center. Patient demographics, symptoms, and medication use were recorded in an outpatient setting. After Bravo capsule placement, patients were followed to determine whether the results of the Bravo capsule study changed clinical management.
Fifty children (mean+/-SD=13+/-3 y; 52% female) were studied; no complications occurred. Reflux symptoms (40%), abdominal pain (18%), and nausea/vomiting (14%) were the 3 most common symptoms leading to Bravo capsule placement. Nearly all studies (96%) were performed off acid-suppressing medications. Results of the Bravo pH study changed clinical care in 88% of children; management changed more frequently in children with an abnormal study (94%) versus those with a normal study (78%; P<0.0001).
The Bravo pH capsule is a safe, well-tolerated test to evaluate acid reflux symptoms in children, and the data obtained frequently changes patient management.
前瞻性评估Bravo pH胶囊在儿童中的耐受性及临床实用性。
酸反流在儿童中很常见，pH检测可用于将酸暴露与症状表现相关联。Bravo胶囊在儿童中的耐受性及临床实用性尚未得到前瞻性评估。
这是一项在学术医疗中心进行的前瞻性、开放标签试验。在门诊环境中记录患者的人口统计学信息、症状及用药情况。放置Bravo胶囊后，对患者进行随访，以确定Bravo胶囊研究结果是否改变了临床管理。
共研究了50名儿童（平均±标准差=13±3岁；52%为女性）；未发生并发症。反流症状（40%）、腹痛（18%）和恶心/呕吐（14%）是导致放置Bravo胶囊的3种最常见症状。几乎所有研究（96%）都是在停用抑酸药物的情况下进行的。Bravo pH研究结果改变了88%儿童的临床治疗；研究结果异常的儿童（94%）与研究结果正常的儿童（78%）相比，治疗改变更为频繁（P<0.0001）。
Bravo pH胶囊是一种安全、耐受性良好的检测儿童酸反流症状的方法，所获得的数据经常会改变患者的治疗方案。
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