Brunasso Alexandra Maria Giovanna, Delfino Chiara, Ketabchi Sheyda, Difonzo Elisa Margherita, Massone Cesare
Department of Dermatological Sciences, University of Florence Medical School, Florence, Italy.
Acta Dermatovenerol Alp Pannonica Adriat. 2009 Mar;18(1):24-7.
Radiation therapy, even at low doses, can induce a wide spectrum of vascular skin proliferations ranging from nonmalignant ones, such as benign lymphangiomatous papules (BLAP), to frankly malignant pathologies, such as angiosarcoma. We describe a 50-year-old Caucasian woman with a past history of uterine rhabdomyosarcoma, treated 22 years prior with surgical excision, chemotherapy, and radiotherapy. She presented with a few skin-colored papules and a clear discharge located in the previously irradiated area (right inguinal region). Histopathology showed a proliferation of irregular, interanastomosing vascular channels, thin walled and lined by prominent endothelial cells with focally hobnail features. Cytological atypia of endothelial cells, mitotic figures, hemorrhagic areas, and necrosis were not observed. The endothelial cells expressed D2-40 and CD31. A diagnosis of BLAP following radiotherapy for uterine rhabdomyosarcoma was made. The patient was treated with complete excision using electrodessication. At the 20-month follow-up visit the patient was still free of recurrence.
放射治疗，即使是低剂量，也可诱发多种血管性皮肤增生，范围从非恶性病变，如良性淋巴管瘤性丘疹（BLAP），到明显的恶性病变，如血管肉瘤。我们描述了一名50岁的白种女性，既往有子宫横纹肌肉瘤病史，22年前接受了手术切除、化疗和放疗。她在先前接受放疗的区域（右腹股沟区）出现了一些肤色丘疹和清亮分泌物。组织病理学显示不规则、相互吻合的血管通道增生，壁薄，内衬突出的内皮细胞，具有局灶性鞋钉样特征。未观察到内皮细胞的细胞学异型性、有丝分裂象、出血区和坏死。内皮细胞表达D2-40和CD31。诊断为子宫横纹肌肉瘤放疗后发生的BLAP。患者接受了电干燥完全切除治疗。在20个月的随访中，患者仍无复发。
