Sun Y, Peng Z-L
Department of Obstetrics and Gynecology, West China Second Hospital, West China Center of Medical Sciences, Sichuan University, Chendu, Sichuan, China.
Postgrad Med J. 2009 Mar;85(1001):134-40. doi: 10.1136/pgmj.2008.072629.
Programmed cell death (PCD) is an important terminal pathway for cells of multicellular organisms, and is involved in a variety of biological events that include morphogenesis, maintenance of tissue homeostasis, and elimination of harmful cells. Dysfunction of PCD leads to various diseases in humans, especially various cancers. Accumulating evidence indicates that PCD is closely related to anti-cancer therapy. Recently, many studies have subdivided PCD into the three categories: apoptosis, autophagy, and programmed necrosis, based on criteria such as morphological alterations, initiating death signal, and the activation of caspases. In this article, we will review the main features and functions of all three types of programmed cell death, focusing on their roles in tumour cells and the relationship of the three types of cell death in anti-cancer therapy.
程序性细胞死亡（PCD）是多细胞生物体细胞的重要终末途径，参与多种生物学事件，包括形态发生、组织稳态维持以及清除有害细胞。PCD功能障碍会导致人类多种疾病，尤其是各种癌症。越来越多的证据表明，PCD与抗癌治疗密切相关。最近，许多研究根据形态学改变、起始死亡信号和半胱天冬酶激活等标准，将PCD细分为三类：凋亡、自噬和程序性坏死。在本文中，我们将综述这三种程序性细胞死亡类型的主要特征和功能，重点关注它们在肿瘤细胞中的作用以及这三种细胞死亡类型在抗癌治疗中的关系。
