Deshmukh Manjeet, Kutscher Hilliard, Stein Stanley, Sinko Patrick
Department of Pharmaceutics, Rutgers University, Piscataway, NJ 08854, USA.
Chem Biodivers. 2009 Apr;6(4):527-39. doi: 10.1002/cbdv.200800277.
In the present in vitro studies, evidence is provided showing that glutathione (GSH) can undergo spontaneous, nonenzymatic auto-degradation. The initial cleavage of the Glu-Cys bond involves nucleophilic attack of the N-terminal amino group of GSH at the gamma-carbonyl side chain, followed by an unusual cleavage of the Cys-Gly amide bond that is complete within 3-5 weeks in the physiological pH range. These observations may be useful for the development of novel biodegradable polymers and releasable prodrugs for sustained and targeted drug delivery applications.
在目前的体外研究中,有证据表明谷胱甘肽(GSH)可发生自发的非酶促自动降解。Glu-Cys键的初始断裂涉及GSH的N端氨基对γ-羰基侧链的亲核攻击,随后是Cys-Gly酰胺键的异常断裂,在生理pH范围内3-5周内完成。这些观察结果可能有助于开发用于持续和靶向药物递送应用的新型可生物降解聚合物和可释放前药。