库欣综合征作为儿童肾肿瘤的首发症状。

Cushing syndrome as a presenting symptom of renal tumors in children.

作者信息

Segers H, van der Heyden J C, van den Akker E L T, de Krijger R R, Zwaan C M, van den Heuvel-Eibrink M M

机构信息

Department of Pediatric Oncology/Hematology, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands.

出版信息

Pediatr Blood Cancer. 2009 Aug;53(2):211-3. doi: 10.1002/pbc.22021.

DOI:10.1002/pbc.22021

PMID:19353619

Abstract

Cushing syndrome as the presenting symptom of a malignant renal tumor in children is rare. We report the first case of paraneoplastic Cushing syndrome due to a Wilms tumor, in which clinical and biological signs of hypercortisolism regressed during preoperative chemotherapy. Additionally, we reviewed the literature on paraneoplastic Cushing syndrome secondary to pediatric renal tumors.

摘要

库欣综合征作为儿童恶性肾肿瘤的首发症状较为罕见。我们报告了首例因肾母细胞瘤导致的副肿瘤性库欣综合征病例，该病例中皮质醇增多症的临床和生物学体征在术前化疗期间有所消退。此外，我们还回顾了有关小儿肾肿瘤继发副肿瘤性库欣综合征的文献。