Fonteyne Valérie, Villeirs Geert, Lumen Nicolaas, De Meerleer Gert
Department of Radiotherapy, Ghent University Hospital, Belgium.
Radiother Oncol. 2009 Jul;92(1):42-7. doi: 10.1016/j.radonc.2009.03.013. Epub 2009 Apr 6.
Urinary toxicity plays a major role in the quality of life (QOL) of patients treated with external beam radiotherapy as primary therapy for prostate cancer. In this study we report on: (1) Incidence of acute and late GU toxicity after intensity modulated radiotherapy (IMRT) for prostate cancer at Ghent University Hospital (GUH). (2) Time evolution of pre-IMRT and IMRT-induced acute and late GU toxicity.
At GUH, 260 patients with a follow-up of > or = 12 months were treated with IMRT for prostate cancer. The incidence and evolution of GU toxicity were recorded.
Acute grades 3, 2 and 1 GU toxicity occurred in 8%, 42% and 42% of the patients, respectively. Late grades 3, 2 and 1 GU toxicity occurred in 3%, 19% and 40% of the patients, respectively. During therapy baseline grade 1 symptoms increased into grade 2 acute GU toxicity in 48%. After 1 and 2 years, 60% and 70% of the patients, respectively, had less GU symptoms when compared to the pre-treatment status.
IMRT induces mild GU toxicity. There is an improvement in pre-IMRT obstructive miction disorders.
尿路毒性在接受体外束放射治疗作为前列腺癌主要治疗手段的患者生活质量（QOL）中起主要作用。在本研究中，我们报告：（1）根特大学医院（GUH）对前列腺癌进行调强放射治疗（IMRT）后急性和晚期泌尿生殖系统毒性的发生率。（2）IMRT前及IMRT诱发的急性和晚期泌尿生殖系统毒性的时间演变。
在GUH，260例随访时间≥12个月的前列腺癌患者接受了IMRT治疗。记录泌尿生殖系统毒性的发生率和演变情况。
急性3级、2级和1级泌尿生殖系统毒性分别发生在8%、42%和42%的患者中。晚期3级、2级和1级泌尿生殖系统毒性分别发生在3%、19%和40%的患者中。在治疗期间，48%的基线1级症状患者进展为2级急性泌尿生殖系统毒性。1年和2年后，分别有60%和70%的患者与治疗前相比泌尿生殖系统症状减轻。
IMRT诱发轻度泌尿生殖系统毒性。IMRT前的梗阻性排尿障碍有所改善。
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