髓鞘水分数分析的可重复性：基于感兴趣区和体素分析方法的比较。
Reproducibility of myelin water fraction analysis: a comparison of region of interest and voxel-based analysis methods.
机构信息
Department of Physics, University of Alberta, Edmonton, Canada.
出版信息
Magn Reson Imaging. 2009 Oct;27(8):1096-103. doi: 10.1016/j.mri.2009.02.001. Epub 2009 Apr 7.
This study compared region of interest (ROI) and voxel-based analysis (VBA) methods to determine the optimal method of myelin water fraction (MWF) analysis. Twenty healthy controls were scanned twice using a multi-echo T(2) relaxation sequence and ROIs were drawn in white and grey matter. MWF was defined as the fractional signal from 15 to 40 ms in the T(2) distribution. For ROI analysis, the mean intensity of voxels within an ROI was fit using non-negative least squares. For VBA, MWF was obtained for each voxel and the mean and median values within an ROI were calculated. There was a slightly higher correlation between Scan 1 and 2 for the VBA method (R(2)=0.98) relative to the ROI method (R(2)=0.95), and the VBA mean square difference between scans was 300% lower, indicating VBA was the most consistent between scans. For the VBA method, mean MWF was found to be more reproducible than median MWF. As the VBA method is more reproducible and gives more options for visualization and analysis of MWF, it is recommended over the ROI method of MWF analysis.
本研究比较了感兴趣区（ROI）和体素基分析（VBA）方法，以确定髓鞘水分数（MWF）分析的最佳方法。20 名健康对照者使用多回波 T2 弛豫序列进行了两次扫描，并在白质和灰质中绘制了 ROI。MWF 定义为 T2 分布中 15 至 40ms 的分数信号。对于 ROI 分析，使用非负最小二乘法拟合 ROI 内体素的平均强度。对于 VBA，获得每个体素的 MWF，并计算 ROI 内的平均值和中位数。与 ROI 方法（R2=0.95）相比，VBA 方法的扫描 1 和 2 之间的相关性略高（R2=0.98），扫描之间的 VBA 均方差异低 300%，表明 VBA 之间的扫描最一致。对于 VBA 方法，发现平均 MWF 比中位数 MWF 更具可重复性。由于 VBA 方法更具可重复性，并为 MWF 的可视化和分析提供了更多选择，因此建议优先使用 VBA 方法进行 MWF 分析。
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