Chu Tongwei, Liu Yugang, Wang Zhengguo, Zhu Peifang, Jiao Wencang, Wen Jianliang, Gong Shuigen
Third Military Medical University of Chinaa, Chongqing, China.
J Trauma. 2009 Apr;66(4):1180-3. doi: 10.1097/TA.0b013e31818b4e61.
To study the role of vascular endothelial growth factor (VEGF) in the process of fracture healing and the effect of VEGF and anti-VEGF polyclonal antibody on fracture healing.
One hundred and five New Zealand white rabbits were subjected to fracture of the middle part of the left radius, and were randomly divided into control, VEGF, and VEGF polyclonal antibody groups. The blood flow at the fracture site was measured by single photoemission computerized tomography after 8 hours, 24 hours, and 72 hours, and 1 weeks, 3 weeks, 5 weeks, and 8 weeks. X-ray films were taken after 1 weeks, 3 weeks, 5 weeks, and 8 weeks to observe the results of fracture healing.
The blood flow at the fracture site in the VEGF group significantly increased compared with the control group during 8 hours to 1 week, but no obvious difference was seen on the X-ray films between the two groups. In the VEGF polyclonal antibody group, the blood flow at the fracture sites decreased significantly at all time points compared with the control group. The fracture healing process was disturbed, and nonunion signs were seen at the fracture site.
The lack of VEGF may impede the fracture healing process, and results in nonunion at the fracture site.
研究血管内皮生长因子（VEGF）在骨折愈合过程中的作用以及VEGF和抗VEGF多克隆抗体对骨折愈合的影响。
105只新西兰白兔行左侧桡骨中段骨折，随机分为对照组、VEGF组和VEGF多克隆抗体组。分别于术后8小时、24小时、72小时、1周、3周、5周和8周时，采用单光子发射计算机断层扫描测量骨折部位的血流量。于术后1周、3周、5周和8周时拍摄X线片，观察骨折愈合情况。
VEGF组骨折部位血流量在8小时至1周期间较对照组显著增加，但两组X线片未见明显差异。VEGF多克隆抗体组骨折部位各时间点血流量均较对照组显著降低。骨折愈合过程受到干扰，骨折部位出现骨不连征象。
VEGF缺乏可能会阻碍骨折愈合过程，并导致骨折部位骨不连。
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