口腔鳞状细胞癌累及下颌下腺罕见。
Rare involvement of submandibular gland by oral squamous cell carcinoma.
作者信息
Chen Tseng-Cheng, Lo Wu-Chia, Ko Jenq-Yuh, Lou Pei-Jen, Yang Tsung-Lin, Wang Cheng-Ping
机构信息
Department of Otolaryngology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
出版信息
Head Neck. 2009 Jul;31(7):877-81. doi: 10.1002/hed.21039.
BACKGROUND
The true involvement of the submandibular gland in primary oral cancer seems quite uncommon.
METHODS
We retrospectively reviewed the pathologic records of 342 patients with oral squamous cell carcinoma who underwent wide excision of primary oral cancer and simultaneous neck dissection from January 2000 to December 2003.
RESULTS
Of the 383 submandibular glands, only 7 (1.8%) exhibited tumor involvement. Of them, 5 glands were involved by direct extension from the primary tumor. One gland showed local invasion from an adjacent involved lymph node in level I and 1 was from intraglandular lymph node metastasis. All of these 6 tumors with submandibular gland involvement were T4 disease (p = .0003) and the neck nodal status on each was more than N2b (p < .0001).
CONCLUSION
The patients with early-stage oral squamous cell carcinoma with preoperative N0 neck may be candidates for preservation of the submandibular gland.
背景
颌下腺真正累及原发性口腔癌似乎相当少见。
方法
我们回顾性分析了2000年1月至2003年12月期间342例行原发性口腔癌广泛切除及同期颈部清扫术的口腔鳞状细胞癌患者的病理记录。
结果
在383个颌下腺中，仅有7个（1.8%）显示有肿瘤累及。其中，5个腺体因原发性肿瘤直接蔓延而受累。1个腺体显示来自Ⅰ区相邻受累淋巴结的局部侵犯，1个来自腺内淋巴结转移。所有这6例累及颌下腺的肿瘤均为T4期疾病（p = 0.0003），且每例的颈部淋巴结状态均超过N2b（p < 0.0001）。
结论
术前颈部为N0的早期口腔鳞状细胞癌患者可能适合保留颌下腺。
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