定义酶家族的四个空间点。

Four spatial points that define enzyme families.

作者信息

Iván Gábor, Szabadka Zoltán, Ordög Rafael, Grolmusz Vince, Náray-Szabó Gábor

机构信息

Protein Information Technology Group, Eötvös University, 1117 Budapest, Hungary.

出版信息

Biochem Biophys Res Commun. 2009 Jun 12;383(4):417-20. doi: 10.1016/j.bbrc.2009.04.022. Epub 2009 Apr 11.

DOI:10.1016/j.bbrc.2009.04.022

PMID:19364497

Abstract

The catalytic properties of enzymes, containing the Asp-His-Ser triads are deeply investigated for a long time. Serine endopeptidases, cutinases, acetylcholinesterases, cellulases, among other enzymes, contain these triads. We found that solely the geometric properties of just four points in the spatial structure of these enzymes are characteristic to their family.

摘要

长期以来，人们对含有天冬氨酸-组氨酸-丝氨酸三联体的酶的催化特性进行了深入研究。丝氨酸内肽酶、角质酶、乙酰胆碱酯酶、纤维素酶等多种酶都含有这些三联体。我们发现，仅这些酶空间结构中四个点的几何特性就决定了它们所属的家族。