University of Manchester and Central Manchester and Manchester Children's University Hospitals NHS Trust, St Mary's Hospital, UK.
Eur J Hum Genet. 2009 Nov;17(11):1381-5. doi: 10.1038/ejhg.2009.60. Epub 2009 Apr 15.
Risk-reducing salpingo-oophorectomy is currently advocated for the reduction of both breast and ovarian cancer risk in BRCA1/2 carriers, but residual risk of peritoneal primary cancer remains a concern. A sequential series of women attending a single institution for ovarian risk management underwent either risk-reducing surgery or screening. A person-years at risk analysis was used to compare observed versus expected cancers. In total, 300 women underwent risk-reducing salpingo-oophorectomy, including 160 BRCA1/2 mutation carriers. Three occult ovarian cancers were detected at surgery. There have been 2400.4 years of follow-up and 15.79 expected cancers. No peritoneal cancers have occurred. Amongst 503 women controls with 3444.3 years of follow-up, 15.93 ovarian cancers were expected and 17 were found. There were six ovarian cancer-related deaths in the control group compared with one in the surgery group. Risk-reducing salpingo-oophorectomy in a single institution has so far avoided peritoneal cancer incidence.
预防性输卵管卵巢切除术目前被提倡用于降低 BRCA1/2 携带者的乳腺癌和卵巢癌风险，但仍存在腹膜原发性癌症的残余风险。为了进行卵巢风险管理，一系列女性在一家机构接受了预防性手术或筛查。采用个体风险年分析比较观察到的癌症与预期癌症。共有 300 名女性接受了预防性输卵管卵巢切除术，其中包括 160 名 BRCA1/2 基因突变携带者。手术中发现了 3 例隐匿性卵巢癌。目前已经随访了 2400.4 年，预计有 15.79 例癌症发生。未发生腹膜癌。在 503 名对照组女性中，随访时间为 3444.3 年，预计有 15.93 例卵巢癌发生，实际发现了 17 例。对照组中有 6 例与卵巢癌相关的死亡病例，而手术组中只有 1 例。单机构的预防性输卵管卵巢切除术迄今已避免了腹膜癌的发生。
